Devon House was put up for sale, and purchased in 1923 by Reginald Melhado, a successful entrepreneur. The final sale agreement, however, did not include the 51 acres, which the Stiebels purchased from the Anglican Church, but instead, 11 acres of the land. The remaining 40 acres was subdivided to form such roadways as Waterloo and Devon Roads. The Melhados added their touch to the elegant 19th century mansion by moving in their collection of antique furnishings. The lavish parties, which many had come to love at Devon House, had significantly reduced when the Melhados occupied the home. It was said that Irene Melhado never liked Devon House because it was too big. It was no surprise then, when the Melhados sold the home only after five years of residing at Devon House.

The new homeowners the Lindos brought back vitality and pageantry to Devon House, and fancy dinner parties at Devon House were widely discussed in Kingston and St. Andrew. Agnes Lindo became known as a hostess with exquisite taste, and nothing was spared when it came to financing entertainment at the Mansion. Funding these lavish events never appeared to be a worrying factor for Cecil Lindo who had become a very successful businessman in Jamaica. He was known as a smart and savvy businessperson, and made some wise investments early in life including investments in the banana industry in Costa Rica, and the purchase of J. Wray and Nephew and Monymusk Estate. He was also a railway magnate and the owner of Appleton Estate and the wine and spirit business Daniel Finzi and Co. Limited. Cecil Lindo died of a heart attack in 1960 at the age of 89. He left Devon House to his wife, but she did not remain at the home. Agnes opted to live in New York following her husband’s death, and it was then that developers approached her regarding the sale of Devon House, to accommodate the construction of condominiums.